Cell Signaling

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What Is Metallic Bonding? The Sea of Electrons

You've met ionic bonds (electrons transferred) and covalent bonds (electrons shared). But what holds a lump of pure copper or iron together, when there's only one kind of atom and nobody to trade with? That's the job of the third great bond type: metallic bonding . The short answer: metallic bonding is the attraction between positively charged metal ions and a " sea " of shared, freely moving electrons. Metal atoms give up their outer (valence) electrons into a common pool that flows through the whole structure, and the electrostatic pull between the fixed positive ions and this mobile electron sea holds the metal together. What metallic bonding actually is Picture a metal as a neat 3D lattice of positive ions (metal atoms that have released their valence electrons) sitting in a shared pool of those delocalised electrons . "Delocalised" means the electrons don't belong to any single atom — they roam freely across the entire piece of metal. The...
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The structure of Chimeric Antigen Receptor (CAR) III - Transmembrane Domains

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Transmembrane Domains Among the four components of a chimeric antigen receptor (CAR), the transmembrane domain is the least studied one. How different transmembrane domains affect and contribute to each other's functions is also not well studied. That being said, we will go through the function of a transmembrane domain of a CAR, the CD3ζ transmembrane domain, and the CD8α transmembrane domain.  Introduction of the transmembrane domain The transmembrane domain is where the transmembrane proteins are located. In a CAR, the transmembrane domain has the function to anchor the CAR to the T cell membrane. How strong the CAR is anchored to the T cell membrane affects the CAR expression level and stability.  Currently, the commonly used transmembrane domain is derived from proteins such as CD3ζ, CD4, CD8α, and CD28. The CD3ζ transmembrane domain Among the transmembrane domains mentioned, the CD3ζ transmembrane may improve CAR-mediated T cell action as the CD3ζ transmembrane medi...
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What is Pepsin?

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In Your Body... Pepsin is a digestive enzyme that performed the best in the acidic condition (pH 2) produced by the gastric juice. It digests and breaks down protein (e.g. meat, seeds, eggs, dairy products, etc.). Keep in mind that pepsin digests proteins (not carbohydrates, not fat) into peptides. These peptides are then either absorbed in the intestine or further break down by enzymes from pancreas. In small intestine (pH around 7), pepsin is no longer effective and no longer digests proteins. Hormones Hormones that regulate digestion and hunger such as gastrin and secretin stimulates the production of pepsinogen, the proenzyme of pepsin. In other words, when pepsinogen is activated, it becomes pepsin.
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